R. Sanz, V. Guilarte, N. García
Sep 7, 2010
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0
Influential Citations
22
Citations
Journal
Organic & biomolecular chemistry
Abstract
A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.