J. Beyer
Jul 1, 1998
Citations
0
Influential Citations
10
Citations
Journal
Synthesis
Abstract
: 4-Hydroxy[1-13 C]benzoic acid ( 5 ) was synthesized starting from commercially available sodium [2-13 C]acetate (1) by a 4-step sequence in an overall yield of 55–65% . Key step in this synthesis is the formation of the benzene ring by base-catalyzed condensation of diethyl [2-13 C]malonate ( 3 ) with 4 H -pyran-4-one. Acid 5 or its ethyl ester could be converted into 3,4-di-hydroxy[1-13 C]benzoic acid ( 9 ), D,L-[1 ¢ - 13 C]tyrosine ( 14 ) and 1,2,4-trihydroxy[4-13 C]benzene ( 19 ) with high efficiency.