B. Ye
2011
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Journal
Fine Chemical Intermediates
Abstract
The asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to the title compound(i.e.(R)-oxyracetam)catalyzed by Saccharomyces cerevisiae and followed with the condensation of 2-amino-acetamide in alkaline solution was investigated.The target compound was obtained in 52.7% yield and confirmed by specific rotation and 1H NMR.