L. Hong-li
2003
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To look for a new method of synthesizing 4-hydroxyindole and 4-methoxyindole.Methods and Results Through the reaction of alkylation of substituted phenols,hydrolysis and cyclization,“vicarious nucleophilic substitution of hydrogen(VNS)” was used to synthesize 4-hydroxyindole and 4-methoxyindole,the method is simple and the cost is low.Conclusion The overall yields of 4-hydroxyindole and 4-methoxyindole are 57.4% and 28.8%,respectively.The process is cheaper and simpler.