Chen Wei-min
2010
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Journal
Chemical Reagents
Abstract
The method for synthesis of the natural compound 4-(hydroxymethyl)-2(5H)-furanone was improved by starting from tris(hydro-xymethyl)aminomethane hydrochloride,via a procedure of protecting two hydroxyl groups and formation of ketone through oxidation,followed by reacting with(ethoxycarbonylmethylene)triphenyl phosphonium ylide,and deprotection and cyclization as lactone.The overall product yield reached 23%.Its effects on pseudomonas aeruginosa biofilm were assayed,and the test results showed that the title compound acted as weak inhibitor on the bacterial biofilm formation.