Wang Yao-xuan
2012
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Journal
Journal of Hebei University
Abstract
The target compound was obtained by condensation and reduction from phenol,50% glyoxylic acid,and sodium bisulfite.The mass fraction and purity of 4-hydroxyphenyl acetic acid,determined by HPLC,were 97.5% and 99.65% respectively.The yield of sodium-4-hydroxyphenyl acetic acid reached 85% when the molar ratio of glyoxylic acid,phenol and sodium hydroxide was 1∶1.5∶2.5.The reductive reaction was performed at 100 ℃,under the pressure of 0.10-0.15 MPa,at 1∶1.1 molar ratios of sodium-4-hydroxymandalate monohydrate to sodium bisulfite.This method has a better industrial prospects by its extensive raw material,simple process,lower cost,better product quality and environmental protection.