Marcia de Figueiredo, P. Oczipka, R. Fröhlich
Jan 10, 2008
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0
Influential Citations
12
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Journal
Synthesis
Abstract
Maleimidoalkanoic acids and their activated derivatives, such as their N-hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography-free preparation of 4-maleimidobutyric acid on a one-mole scale.