Hai-Shan Jin, Li‐Ming Zhang, Zhiqing Yan
Mar 1, 2012
Citations
0
Influential Citations
1
Citations
Journal
Journal of Chemical Research
Abstract
4-Methoxysalicylaldehyde, a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents. 4-Methoxysalicylaldehyde can be synthesised via selective monomethylation of 2,4-dihydroxybenzaldehyde in toluene in the presence of NaHCO3 in higher yield using cheaper reagents with little production of dimethylation product compared to previous methods. The location of the methoxyl group was confirmed by conversion to 3-acetyl-7-methoxycoumarin by condensation with ethyl acetoacetate.