V. P. Chekhun, E. Zvonkova, M. Struchkova
1974
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Journal
Chemistry of Heterocyclic Compounds
Abstract
Abstract3-Hydroxy-5-hydroxymethyl-2-methylpyridine (4-norpyridoxine) has been synthesized by the heterodiene condensation of 4-methyl-5-propoxyoxazole and 5-ethoxy-2,5-dihydrofuran-2-one through the stage of 3-hydroxy-2-methylpyridine-5-carbaldehyde with reduction of the latter by NaBH4. One of the isomeric adducts has been isolated, and its stereochemistry has been established by PMR spectroscopy.