Chen Zhao
2002
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Journal
Fine chemicals
Abstract
N Phenylamino) benzoic acid(Ⅲ) was synthesized from p aminobenzoic acid.Esterification of p aminobenzoic acid was carried out by adding p aminobenzoic acid into ethanol in the presence of dry hydrogen chloride and refluxing for 12 h.Then the reaction mixture was regulated to pH=8 with solution of sodium carbonate to give ethyl p aminobenzoate(Ⅰ) in 77.7% yield.Ⅰwas treated with acetic anhydride for 8 h at 130-140 ℃,giving ethyl p acetylaminobenzoate(Ⅱ) in 93.3% yield.The mixture of Ⅱ ,copper dust and potassium carbonate was refluxed for 18 h in nitrobenzene.Then nitrobenzene was removed through steam distillation,and sodium hydroxide was added to the mixture which was refluxed for 1 5 hours.At last the reaction mixture was acidified to give the title product Ⅲ in 61.3% yield.