G. Harriman, S. Chi, Min Zhang
Apr 28, 2003
Citations
0
Influential Citations
29
Citations
Journal
Tetrahedron Letters
Abstract
The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions.