M. Bhupathy, D. Conlon, K. Wells
Jul 1, 1995
Citations
0
Influential Citations
27
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2-furoate.