Li Fu-gang
2006
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Journal
Fine and Specialty Chemicals
Abstract
2-Amino-4-chlorocyanobenzene was prepared from 4-chloro-2-nitrobenzoic acid by cyanidation of methyl sulfonylamide and phosphorus pentachloride at first, then hydrogenation was carried out in the presence of Pt-C catalyst. After that the 2-amino-4-chlorocyanobenzene was reacted with sodium azide to form cyclic tetrazole i.e. 5-(2-amino-4-chloro)phenyltetrazole, the final product was obtained with a total yield of 70%, calculated based on 4-chloro-2-nitrobenzoic acid. The content of title product was 99% proved by HPLC. The structure of 5-(2-amino-4-chloro) phenyltetrazole was confirmed by IR, ~1HNMR and MS.