Mitesh B. Vekariya, Tejal D. Bhatt, H. Joshi
2022
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Journal
Asian Journal of Organic & Medicinal Chemistry
Abstract
In present study, an efficient and greener protocol is developed for the synthesis of 5-(4-(substituted [1,1′-biphenyl]-4-yl-methoxy)benzyl)-thiazolidine-2,4-diones by using microwave irradiations. Here, a one-pot reaction between 5-(4-((4-bromobenzyl)oxy)benzyl)thiazolidine-2,4-dione, substituted aryl boronic acid and K2CO3 in the presence of toluene:water:ethanol solvents under conventional heating methods and microwave irradiation methods is reported. All the final compounds were characterized by FT-IR, 1H NMR, 13C NMR and mass spectroscopic analysis. The antimicrobial evaluation studies show moderate activities against used microbes.