N. Muller
Jul 1, 1987
Citations
0
Influential Citations
17
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Three methods of synthesis are described for 2-amino-3-methyl-5,5,5-trifluoropentanoic acid, a mixture of diastereomers which on separation afford the title compounds. The least cumbersome involves bromination and subsequent amination of 3-methyl-5,5,5-trifluoropentaonic acid, with overall yields near 45% in several trials. The starring materials is readily obtainable from the products of an anodic trifluoromethylation of menthallyl cyanide.