K. Kobayashi, Hideki D. Shimizu, M. Itoh
Aug 1, 1990
Citations
0
Influential Citations
17
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
An efficient new synthesis of 5,7-dihydroxy-4-methylisobenzofuran-1(3H)-one, a metabolite of aspergillus flavus and a key intermediate in the synthesis of mycophenolic acid, is reported. The new synthesis involves the preparation of 1,2-dihydro-4,6-dimethoxy-3-methylbenzocyclobuten-1-ol and a regioselective β-scission of alkoxyl radical generated from it with lead tetraacetate as the key steps.