V. Tyvorskii, D. N. Bobrov, O. Kulinkovich
Mar 3, 2001
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron
Abstract
Abstract 5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines, afforded trifluoromethylated 1H-pyrazolo[4,3-c]pyridines.