V. Patil, Ashish Asrondkar, S. Pande
2013
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0
Influential Citations
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Quality indicators
Journal
IOSR Journal of Pharmacy and Biological Sciences
Abstract
In this work, we evaluate the biological activities of some new derivatives of benzofuran which can be used as effective anti-microbial agents. The recent reviews of literature have highlighted the attention of medicinal chemists because of their diverse biological activities and profound efficacy. Clinically potent benzofurans generated interest to construct a system which possesses anti-bacterial and anti-fungal activity. Furan and benzofuran are associated with wide spectrum of biological activity. In the view of these, an effort was made to check some synthesized compounds for their anti-microbial activity. In present study, pyrazoline derivatives were synthesized; 5-bromo-3-methyl acetophenone undergoes ring formation in presence of chloroacetone to form benzofuran which further forms chalcone on treatment with substituted benzaldehyde. This intermediate on treatment with hydrazine hydrate results into pyrazoline. Further it reacts with various benzoyl chlorides to form the titled product. Synthesized compounds have been confirmed on the basis of spectral studies and analytical data. All the compounds were screened for their in- vitro anti-bacterial activity against Gram positive Staphylococcus aureus ATCC3750 and Gram negative Salmonella typhi NCTC786, anti-fungal strains of Candida albicans ATCC10233 and Aspergillus niger ATCC