Dmitry S. Belov, V. Ivanov, F. Curreli
Apr 18, 2017
Citations
0
Influential Citations
11
Citations
Journal
Synthesis
Abstract
Abstract 5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.