Chen Fan
2009
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Journal
Fine chemicals
Abstract
5-Chloro-2-methoxycarbonyl-1-indanone was prepared from 5-chloro-1-indanone in the presence of sodium hydride(NaH),using dimethyl carbonate(DMC) as methoxycarbonylation agent instead of conventional toxic reagents.The best yield(86.09%) of the title compound was obtained under optimized conditions that n(5-chloro-1-indanone)∶n(NaH)=1∶3,reaction temperature was 90 ℃ and dropping time was 30 min.The structure of the target compound was characterized through FTIR,1HNMR,13CNMR and MS.The infrared spectrum and melting range of the product were in good agreement with those reported in literature.