Wu Ming
2001
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Journal
Fine chemicals
Abstract
Synthesis of 5 chloroindol 2(3H) one was studied with 4 chloroaniline and chloroacetyl chloride as raw materials through chloroacetylation and Friedel Crafts reaction.Effects of reaction temperature,solvent and molar ratio of raw materials on the yield were investigated.The optimum reaction conditions were obtained.In the first step,at room temperature with acetic acid as solvent and molar ratio of 4 chloroaniline to cholroacetyl chloride 1.5∶1.0,the yield of chloroacetylation was 98%. In the second step, with monochlorohexane as solvent at 120-125 ℃,the yield of cyclization reaction could reach 95%.Purity of the final product was 99.5%.