V. Nair, P. Sharma
Aug 7, 2003
Citations
0
Influential Citations
5
Citations
Journal
Arkivoc
Abstract
4(S)-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2(S)-ylmethyl phosphonic acid, a 5′-Cphosphonate analog of the potent anti-HIV compound S,S-IsoddA, was synthesized in order to bypass the critical initial intracellular phosphorylation. Key phases in this multistep synthesis were the Arbuzov reaction of the 5-iodofuranose with triethylphosphite and the Mitsunobu/ coupling reaction of the phosphonate with adenine. The structure of the final product was confirmed by HRMS and multinuclear NMR data.