G. Shi, Yuanyao Xu, Ming‐Hua Xu
Apr 15, 1991
Citations
0
Influential Citations
18
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract 5-Ethoxy-4-(trifluoromethyl)-2-oxazolecarboxylic acid 4 hasbeen obtained from the corresponding ethyl ester prepared byrhodium-catalysed reaction of ethyl 3,3,3-trifluoro-2-diazopropionate1 with ethyl cyanoformate. Starting from this acid, anumber of its ester and amide derivatives have been prepared ingood yields. The acid 4 was found to decarboxylate readily onheating to give the simple CF 3 -substituted oxazole 5, which wasfurther utilized as an aza-diene for the synthesis of 3-hydroxy-2-trifluoromethyl-4-pyridinecarboxylic acid from acrylic acid.