P. Bhatt, P. Patel
Jan 31, 2006
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Journal
ChemInform
Abstract
5H-Dibenzo(b,f)azepine-5-carbonyl chloride 1 has been prepared from 5H-dibenzo(b,f)azepine by phosgenation, which has been then treated with hydrazine hydrate to give 5H-dibenzo(b,f)azepine-5-acid hydrazide 2. It has been reacted with various aromatic aldehydes to afford 5H-dibenzo(b,f)azepine-5-carboxylic acid-(substitutedbenzylidene)hydrazide 3a-j. The synthesis of 5H-dibenzo(b,f)azepine-5-carboxylic acid [3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl]amide 4a-j has been achieved by the reaction of 3 with chloroacetyl chloride in presence of triethylamine. The products have been characterized by elemental analysis, IR, H NMR and mass spectral studies.