Luo Xiao
2003
Citations
0
Influential Citations
0
Citations
Journal
Journal of China Pharmaceutical University
Abstract
AIM:The purpose is to develop the general process for the synthesis of 5-HT 3 receptor antagonist Azasetron Hydrochloride. METHOD: It was synthesized from methyl 5-chloro-2-hydroxyl benzoic acid via nine-step reaction with nitration,reduction,etc. RESULT: The title compound was obtained with 40% overall yield. The structure was confirmed by IR, 1 HNMR and MS. CONCLUSION:Some improvements for the synthesis of Azasetron Hydrochloride were made.