Zhongren Lin, Lingfeng Tong, Hong Qiu
May 4, 2022
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Journal
SynOpen
Abstract
The 5-Hydroxybenzofurans exhibit multi-biological activities, many chemical compound may become clinical treatment drug. In this paper, 5-hydroxybenzofurans are prepared by PIDA mediated oxidation and coupling-cyclization of β-dicarbonyl compounds and hydroquinones. The reactions make functionalization directly to aromatic C(sp2)-H of hydroquinones, and the yield of target molecule is up to 96%.