H. Masui, Kohei Naito, Mai Minoshima
Mar 16, 2021
Citations
0
Influential Citations
2
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
An efficient method for the synthesis of substituted 5-(hydroxymethyl)piperazin-2-ones was established by using an automated synthesis process. Thirteen piperazinones were synthesized from chiral α-bromocarboxylic acids and Garner's aldehyde which were prepared by using our originally developed automated synthesizer, ChemKonzert®. The automated method of synthesizing chiral α-bromocarboxylic acids was efficient and safe because the rate of the dropwise addition of the reagent can be controlled using the automated synthesizer. This method is expected to contribute to the synthesis of pharmaceuticals. 2009 Elsevier Ltd. All rights reserved.