陶李明, 刘文奇, 谭倪
2010
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Abstract
5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material.Effects including catalysts on acylation reaction,solvents on iodocyclization and catalysts,ligand,base and reaction temperature on Suzuki cross-coupling reaction have been investigated.Under optimum conditions,the yield of the product was up to 68.5%.The chemical structures of the intermediates and target product were characterized by IR,NMR and MS spectra.