Zhang Rong
2000
Citations
0
Influential Citations
1
Citations
Journal
Fine chemicals
Abstract
Methyl 2 thiazolamine was obtained through multistep reactions with propionaldehyde, acetic anhydride and thiourea. Propionaldehyde reacted with acetic anhydride in the presence of sodium acetate to give enol acetate which added bromine rapidly,and 2 bromo 1, 1 dimethoxypropane was obtained through alcoholysis. The yield was 41 5%. After hydrolysis,α bromopropionaldehyde was prepared. The yield was 71 4%. α Bromopropionaldehyde condensed with thiourea to give 5 methyl 2 thiazolamine. The yield was 61 2%. The yield was higher and the reaction was easy to control . This method provided a better way to get 5 methyl 2 thiazolamine and α bromopropionaldehyde and was applicable to the batch production.