Chen Pei
2012
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Journal
Fine Chemical Intermediates
Abstract
5'-Nitro-[2,2'-bithiophene]-5-carbaldehyde was synthesized via Suzuki coupling reaction using 5-nitro-2-bromothiophene and 5-formyl-2-thiopheneboronic acid as the starting materials.The influences of various bases,solvents,catalysts and addition sequence of materials on the coupling reaction were investigated.The results showed that the optimum reaction conditions were using DME as the solvent,NaF as the base,Pd/C as the catalyst and all were in one-pot.