Zhao Yi-min
2011
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Journal
Pharmaceutical Journal of Chinese People's Liberation Army
Abstract
Objective To synthesize 4-methylnicotinonitrile derivatives.Methods New 5-substituted derivatives of 4-methylnicotinonitrile were synthesized through ozonization-reduction,chloration,wittig-reaction and acidic hydrolyzation using 4-methyl-5-vinylnicotinonitrile as the starting material.Results Four new compounds were synthesized with a yield of over 70%.Their structures were verified by MS and 1H-NMR.Conclusion This synthetic procedure is user-friendly under mild reaction conditions and the product can be used in the synthesis of pyridine-type alkaloids.