Shengqiang Wang, Zhiyue Geng, Guo Ruiyun
Jul 20, 2016
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Various 5-substituted-3-pyridazine carbonitrile derivatives were synthesized by regioselective Reissert-type reaction with 4-substituted pyridazine, 4-methylbenzene-1-sulfonyl chloride and trimethylsilyl cyanide. The reaction can be carried out under conditions of AlCl3 as catalyst, THF as solvent at 10 °C, followed by treatment with DBU which gave moderate yields and good regioselectivity.