Jane L. Humphreys, David J Lowes, Karen A. Wesson
Apr 19, 2004
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of 6,6-difluoroshikimic acid ( 4 ) has been achieved in nine steps from the enantiopure diol 9 , which is derived from microbial dihydroxylation of iodobenzene. The synthetic strategy has also been demonstrated to be applicable to the preparation of other 6-substituted analogues of shikimic acid.