N. Minami
Jun 1, 1981
Citations
0
Influential Citations
1
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Synthesis of 6,7-dihydro-10-trideuteromethyl-6,8,8-trimethyl-8H-pyrano[3,2-g] chromone-2-carboxylic acid (10) in high isotopic purity is described. The trideuteromethylation was achieved by sodium borodeuteride reduction of the ethoxycarbonyl derivative (5) of 7-hydroxy-2,2,4-trimethylchroman-8-carboxylic acid (4). This labelled compound (10) is required for use as mass spectrometric stable isotope internal standard for the study of metabolic fate of 6,7-dihydro-6,8,8,10-tetramethyl-8H-pyrano[3,2-g] chromone-2-carboxylic acid (9), which is an orally active antiallergic agent.