H. V. D. Poel, G. Guillaumet, M. Viaud-Massuard
Feb 11, 2002
Citations
0
Influential Citations
38
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of new tricyclic azaindolic analogs of the hormone melatonin is described. Treatment of 1-(4-bromobutyl)pyrrolo[3,2- b ]pyridine derivative with tributyltin hydride and AIBN results in radical cyclisation to give the 6,7,8,9-tetrahydropyrido[2,3- b ]indolizine ring system. A new synthetic approach of pyridopyrrolo[2,1- b ][1,3]oxazine moiety is shown to be accomplished readily from 1-(3-bromopropyl)-2-oxopyrrolopyridine derivative with sodium hydride in N , N -dimethylformamide.