Liu Xian-min
2014
Citations
0
Influential Citations
0
Citations
Journal
China Surfactant Detergent & Cosmetics
Abstract
First intermediate,4,5-dimethoxysalicylaldehyde was synthesized by demethylation of 2,4,5-trimethoxybenzaldehyde with boron tribromide. The yield is about 64%. Then second intermediate4,5-dimethoxy-2-hydroxy ethyl phenylacrylate was prepared from the first intermediate by reaction with ethyl malonate and the yield is about 79%. Finally the targeted product 6,7-dimethoxycoumarin was synthesized from the second intermediate via cyclization with thionyl chloride and yield is about 51%. All the intermediates and product were characterized by1 HNMR and MS. The results showed that the targeted intermediates and product were prepared as required.