Hideyuki Sugimura, Hisashi Takei
1985
Citations
0
Influential Citations
16
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
6-(Methylthio)purine reacted with RMgX (R=C6H5, CH3(CH2)nCH2 (n=2 to 6), C6H5CH2CH2, (CH3)2 C=CHCH2CH2) in the presence of 5 mol% [NiCl2(Ph2PCH2CH2CH2PPh2)] in refluxing THF for 8 h to afford 6-aryl or 6-alkylpurines in 62–74% yields. By applying this reaction to 6-(methylthio)purine nucleoside, 6-(4-methyl-3-pentenyl)-9-β-D-ribofuranosylpurine was synthesized.