Xu Li-feng
2011
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Journal
Journal of Liaoning University
Abstract
Pyrazolo [1,5-a] pyrimidinies have shown many excellent biological activities in the areas of medicine.In this paper,we report the synthesis and characterization of three new 6-arylsubstituted pyrazolo [1,5-a] pyrimidine derivatives.The intermediate 4-(2,4-dichlorophenyl)-3-methyl-1H-pyrazol-5-amine was synthesized from 2,4-dichlorobenzyl Cyanide,through acetylation with acetyl chloride,followed by condension with hydrazine hydrate;Methyl 4-(trifluoromethyl)benzoate were condensed with acetonitrile to yield 3-oxopropanenitrile that reacted with hydrazine hydrate to yield 3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine.The desired 6-arylsubstituted pyrazolo [1,5-a] pyrimidines are prepared by the reaction of diethyl 2-phenylmalonates with 5-amino-1H-pyrazoles in good yields.The structure of two pyrazolo [1,5-a] pyrimidines was characterized by IR and 1HNMR.