B. Chalyk, A. Isakov, Maryna V. Butko
Aug 24, 2017
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0
Influential Citations
24
Citations
Journal
European Journal of Organic Chemistry
Abstract
New scaffolds for drug discovery, 6-azaspiro[4.3]alkanes, have been synthesized in two steps from four-membered-ring ketones: cyclobutanone, thienone, N-Boc-azetidinone (Boc = tert-butoxycarbonyl), etc. The key transformation was the reaction between electron-deficient exocyclic alkenes and an in-situ generated N-benzylazomethine ylide.