A. R. Kumar, G. Sathaiah, A. C. Shekhar
Aug 1, 2014
Citations
0
Influential Citations
9
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Novel 1-carboxymethyl-6-fluoro-7-cyclic amino-substituted-4-oxo-1,4-dihydroquinolone-3-carboxylic acids 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l, 7m, 7n were synthesized as a new class of quinolones. Ethyl-6-fluoro-7-chloro-1,4-dihydro-4-quinoline-3-carboxylic acid was prepared from conventional method and reacted with ethyl bromoacetate to furnish N-carboxymethyl derivatives. The compounds were screed against various Gram-positive and Gram-negative bacterial strains. Antibacterial activity data is validated by molecular docking studies.