Mudassar A. Sayyed, S. Mokle, Y. Vibhute
Sep 13, 2006
Citations
0
Influential Citations
15
Citations
Journal
Arkivoc
Abstract
Treatment of 3-amino-2-methylquinazolin-4(3H)-one with iodine monochloride or bromine in acetic acid affords the corresponding 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H) -ones in high yields. The notable advantages of this protocol are, no need of catalyst, mild conditions, simple operation and short reaction times with high yields. New potentially active Schiff bases are prepared by condensing these 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H) -ones with different substituted aryl aldehydes. The bioactivity of the synthesized Schiff bases is studied.