S. Xiao-kai
2013
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Journal
Drugs and Clinic
Abstract
Objective To study the synthetic technology of 6-methoxy-7-[(1-methyl-4-piperidine)methoxyl]-4(3H)-quinazolone.Metheds Taking tert-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate and methyl vanillate as the starting material,target compound was obtained after a series of chemical reactions including stripped tert-butoxy carbonyl,methylation,nitrification,reducing reaction,and Niementowski cyclization.Results The overall yield was 56%.Conclusion The improved procedure could reduce the reaction steps and lower the cost of preparation,simplify the reaction operating conditions,increase the yield,and make it more suitable for the industrial requirements.