Jia Ding-xian
2013
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Journal
Laboratory Science
Abstract
6-methyluracil was synthesized from methyl acetoacetate and urea by using sodium bisulfate monohydrate as catalyst and petroleum ether as water-carrying agent.The effects of different factors were investigated.The optimum reaction conditions were as follows: methyl acetoacetate was 0.02mol,ratio of n(methyl acetoacetate):n(urea):n(cat.) was 1:2:0.15,reaction time was 2.5 h,the yield of 6-methyluracil was 86.9%.The method shows the advantages of simple operation,environment friendly and high yield.