Toshio Tanaka, A. Hazato, K. Bannai
1984
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 6-Oxoprostaglandin E1 methyl ester was synthesized in a single pot from ( R )-4- t -butyldimethylsiloxy-2-cyclopentenone by organocopper conjugate addition with an ω side-chain unit, trapping of the resulting enolate with 6-methoxycarbonyl-2-nitrohex-1-ene, and treatment with aqueous titanium(III) trichloride. Hydrolysis of the methyl ester was accomplished by porcine liver esterase. 6-Oxoprostaglandin F1α, was obtained from 6-nitroprostaglandin E1 methyl ester in four steps.