M. Tinti, P. Foresta, E. Quaresima
Nov 1, 1979
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Il Farmaco; edizione scientifica
Abstract
A series of 7-acylamidodesacetoxycephalosporanic acids and analogous pivaloyloxymethyl esters have been prepared and tested in vitro for antibacterial activity. Those acids which exhibited a significant in vitro activity, were also studied in vivo and compared with the corresponding esters. Experiments performed on laboratory animals showed that, after oral administration, the esters were absorbed more efficiently than the corresponding acids.