Cheng Qing-fang
2005
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Journal
Chemical Reagents
Abstract
7-Amino-3-(1-methylpyrrolidinio) methyl-3-cephem-4-carboxylate hydrochloride was synthesized from diphenylmethyl 7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride( ACLH· HCl) by condensation,N-alkylation and hydrolysis in an overall yield of 77.8% without the undesirable byproduct-△ 2 isomer.The purity of the title compound was over 98% by HPLC.This procedure was simple,mild and safe,suitable for scale-up production.