Xue Juanjuan, Li Jiemei, Liu Xiaozhu
2010
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Journal
Modern Food Science and Technology
Abstract
A novel route for 7-Amino-heptanoic acid hydrochloride preparation was developed in this paper by two step of nucleophilic substitution of 1,5-Dibromopentane with potassium phthalimide and diethyl malonate to give N-(5-Bromopentyl)phthalimide.The ester was converted to 7-Amino-heptanoic acid hydrochloride via hydrolyzation and decarboxylation.The total yield of 7-Amino-heptanoic acid hydrochloride was 55%.Structures of the products were confirmed by 1HNMR,LC-ELSD-UV-DAD-MS.The procedure was simple and convenient.