Li Jiu
2010
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Journal
Chinese Journal of Spectroscopy Laboratory
Abstract
7-amino-quinazoline is an important intermediate for synthesizing the heterocyclic drugs.In order to find an economical method to synthesize the 7-amino-quinazoline,7-amino-quinazoline was synthesized from reduction of 4-choloro-7-nitro-quinazoline with Pd/C and Zn,and the yield is 52%,which is little higher than the method has been reported.The method is more economical than the method only using Pd/C as reducer.