A. Kuznetsov, S. Chapyshev
Sep 1, 2007
Citations
0
Influential Citations
3
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
Abstract7-Benzyl-2-pyrrolidin-1-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one was prepared by condensation of 1-benzyl-4-ethoxycarbonyl-3-oxopiperidine with pyrrolidine-1-carboxamidine. Subsequent treatment of the product with trifluoromethansulfonyl anhydride, aqueous ammonia, and hydrogen in the presence of palladium on carbon gave 4-amino-2-pyrrolidin-1-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine in 80% yield. The given compound was used in the reductive amination of aldehydes in the synthesis of various 7-arylmethyl-substituted derivatives of 4-amino-2-pyrrolidin-1-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine.