Jianqing Zhang, Yongli Duan, Hehua Xiong
Jul 9, 2019
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Journal
IOP Conference Series: Earth and Environmental Science
Abstract
7-chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxylic acid is an important intermediate for the many biologically active anticancer drugs. In this research, a rapid and efficient synthesis of compounds 7 was established. Compound 7 consisting of methyl (Z)-2-(2, 5-dichloro-6-fluoronicotinoyl)-3-((4-fluorophenyl) (methyl) amino) acrylate was synthesized by two steps including substitution and hydrolysis. The synthesis method was optimized, and structure was confirmed by 1H NMR and MS spectrum. The synthesis method is optimized. The total yield of the two steps is 63.69%.